Arsenio Paez

Arsenio PaezResearch Fellow at Concordia University and Senior Lecturer at Northeastern University

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Arsenio is an IDEAL Council member and a clinical trials methodologist with a particular interest in study design and clinical trials methods in complex interventions.  His DPhil research at Oxford in intervention fidelity in clinical trials was greatly inspired by the IDEAL framework.

Arsenio’s clinical background is in CNV genetic, neurodevelopmental and neurodegenerative disorders. He is particularly interested in how IDEAL can be applied to trials that combine surgery, medical devices and biologics, such as advanced therapy medicinal products (ATMPs) in regenerative medicine and rehabilitation trials. He is also keenly interested in applying IDEAL to sleep medicine and behavioural neuroscience clinical trials.

Arsenio lead the working group considering when RCTs are, or are not, appropriate for implantable medical devices, and what other study designs or forms of evidence are appropriate instead.

He also lead a real world data working group, and is one of IDEAL’s clinical specialty leads. As a development lead at IDEAL, he is excited to support the development of a North American IDEAL centre and foster greater collaboration between IDEAL centres in the UK, Europe, and Asia.

Arsenio also co-leads a multi-centre working group working to adapt the IDEAL framework to accommodate surgical regenerative medicine trials.

Relevant publications

  1. Paez A, Rovers M, Hutchinson K, Rogers W, Vasey B, McCulloch P. Beyond the RCT: When are randomised trials unnecessary for new implantable therapeutic devices, and what should we do instead? Under review, Annals of Surgery.
  2. Bilbro NA*, Hirst A*, Paez A*, Vasey B, Pufulete M, Sedrakyan A, McCulloch P; IDEAL Collaboration Reporting Guidelines Working Group. The IDEAL Reporting Guidelines: A Delphi Consensus Statement Stage Specific Recommendations for Reporting the Evaluation of Surgical Innovation. Ann Surg. 2021 Jan 1;273(1):82-85. doi: 10.1097/SLA.0000000000004180. PMID: 32649459.  *Co-first authors
  3. Yu J, Hirst A, Yang Z, Zhang Y, Paez A, et al. The methodological quality of systematic reviews with meta-analyses of surgical randomized controlled trials: A cross-sectional survey. Under review, British Journal of Surgery.
  4. Beard D, Hamilton D, Davies L, Cook J, Hirst A, McCulloch P, Paez A. Evidence-based evaluation of practice and innovation in Physical Therapy using the IDEAL-Physio framework. Phys Ther.2018; Feb 98(2), 108-121.